Manchester United hitman Robin Van Persie and former Chelsea star Arjen Robben and were on top form as Holland ran riot against reigning World Cup champions Spain.
Despite a slow start to the game, it was Spain who took the lead after half an hour through a Xabi Alonso penalty.
However, Van Persie levelled for the Dutch a minute before half-time with an early Goal of the Tournament contender, smashing home a flying header after a beautifully-weighted 45-yard pass from Daley Blind.
Robben put Holland 2-1 up in the 53rd minute, his fantastic first touch leaving Gerard Pique in his wake and firing home to send the Dutch fans wild.
RVP hit the bar with a thundering shot before defender Stefan de Vrij headed home from a set-piece for 3-1.
David Silva had a goal disallowed minutes before Van Persie bagged his second of the evening.
Robben rounded off the night with a great solo run and finish, leaving Spain humiliated in their first match in Brazil.